Long-term allograft survival after kidney transplantation.

Abstract

BACKGROUND:

Technical and medical advances over the past few years have produced an important increase in the functionality of renal allografts. The aim of this study was to identify the factors associated with allograft survival 15 years after transplantation in our series.

METHODS:

A retrospective study of kidney transplantations was carried out at Reina Sofia Hospital in Cordoba from February 1979 to December 1997, with follow-up through June 2012. A subanalysis of the series was undertaken, and Kaplan-Meier analysis and Cox proportional hazards model regression used to achieve the main objective of the study.

RESULTS:

A total of 487 renal allografts with a mean follow-up of 114 months were studied, of which 37% (n = 180) survived for >15 years. Of the 180 patients, the main causes of graft failure were chronic allograft nephropathy in 29 (66%) and patient death in 13 (29.5%). Multivariate analysis identified the number of HLA mismatches (hazard ratio [HR] 1.25, 95% CI 1.01-1.56), panel reactive antibodies (HR 2.61, 95% CI 1.28-5.26), and delayed graft function (HR 11.25, 95% CI 1.33-95.28) as being significantly associated with graft loss after 15 years.

CONCLUSIONS:

The high immunologic risk of the patients was independently associated with graft loss. Delayed graft function was the most important factor in the speed of graft failure beyond 15 years.

• Authors: E Gómez Gómez, J P Campos Hernández, F J Márquez López, J Ruiz Garcia, V Garcia Montemayor, F Anglada Curado, M Leva Vallejo, J C Regueiro López, M D Navarro Cabello, P Aljama, M J Requena Tapia
• Journal: Transplantation proceedings (Transplant Proc) Vol. 45 Issue 10 Pg. 3599-602 ( 2013) ISSN: 1873-2623 [Electronic] United States
• PMID: 24314970 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Antibodies
• HLA Antigens

Topics

• Adult
• Allografts
• Antibodies (blood)
• Chi-Square Distribution
• Delayed Graft Function (immunology, mortality)
• Female
• Graft Rejection (immunology, mortality)
• Graft Survival
• HLA Antigens (immunology)
• Histocompatibility
• Humans
• Kaplan-Meier Estimate
• Kidney Failure, Chronic (mortality, surgery)
• Kidney Transplantation (adverse effects, mortality)
• Male
• Multivariate Analysis
• Proportional Hazards Models
• Retrospective Studies
• Risk Factors
• Spain
• Time Factors
• Treatment Outcome
• Young Adult