[Pre- and post-conditioning phenomena: the protective physiological mechanisms in the aspect of pathogenesis and the theory of treatment of ENT pathology].

Abstract

The objective of the present work was to expose the universal general biological significance of the protective pre- and postconditioning phenomena and to provide an insight into the possibility of application of therapeutic modalities based on these effects in current otorhinolaryngological practice. Pre- and postconditioning phenomena (Pre-C and Post-C respectively) began to be studied as protective physiological mechanisms since the 1980s, first in cardiology and thereafter in other fields of experimental medicine. At the same time, their protective properties had been known and intuitively used much earlier among the established human cultural and social stereotypes, psychophysical training techniques, and methods of traditional and empirical medicine. The widespread application of these phenomena gives evidence of their universal biological nature as factors involved in the interactions between the organism and pathogens (including co-morbidity), the process leading to the enhancement of non-specific resistance, mechanisms underlying realization of pharmacodynamic effects of a number of pharmaceutical products,etc. The understanding of the protective potential of PreC and PostC dictates the necessity to revise and further elaborate the present-day strategy of prophylaxis and treatment of the most serious chronic ENT diseases.

• Authors: S G Zhuravskiĭ, M M Galagudza, S A Ivanov
• Journal: Vestnik otorinolaringologii (Vestn Otorinolaringol) Issue 4 Pg. 59-66 ( 2013) ISSN: 0042-4668 [Print] Russia (Federation)
• PMID: 24312957 (Publication Type: English Abstract, Journal Article, Review)

Topics

• Cell- and Tissue-Based Therapy (methods)
• Disease Management
• Humans
• Models, Theoretical
• Otorhinolaryngologic Diseases (therapy)