Recurrent spontaneous abortions, Hashimoto thyroiditis and alopecia totalis: response to anticoagulation and intravenous immunoglobulin therapy.

Abstract

INTRODUCTION:

Although numerous studies indicated a link between antithyroid antibodies and recurrent spontaneous abortions (RSA), consensus on the treatment of this condition is still lacking.

CASE REPORT:

We present a case of a 35-year-old pregnant woman (gestation week 4) with primary hypothyroidism, total alopecia, high level of positive antithyroid antibodies, and history of two recurrent spontaneous abortions in early pregnancy. Along with L-thyroxin substitution, intravenous human immunoglobulin (IVIg) combined with anticoagulation and antiaggregation therapy was introduced. During pregnancy her scalp hair completely re-grew, and following gestation week 39 she delivered healthy female child.

CONCLUSION:

Thyroid antibodies could contribute to previous recurrent abortions in our patient. It is suggested that in older primiparas with Hashimoto thyroiditis and history of RSA, a combined treatment with IVIg, anticoagulation and antiaggregation therapy should be considered.

• Authors: Ivana Bozic Antic, Djuro Macut, Bojana Popovic, Tatjana Isailovic, Milan Petakov, Sanja Ognjanovic, Svetozar Damjanovic
• Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (Gynecol Endocrinol) Vol. 30 Issue 2 Pg. 100-2 (Feb 2014) ISSN: 1473-0766 [Electronic] England
• PMID: 24308767 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticoagulants
• Immunoglobulins, Intravenous
• Thyroxine

Topics

• Abortion, Habitual (drug therapy, etiology)
• Adult
• Alopecia (complications, drug therapy)
• Anticoagulants (therapeutic use)
• Female
• Hashimoto Disease (complications, drug therapy)
• Humans
• Immunoglobulins, Intravenous (therapeutic use)
• Pregnancy
• Pregnancy Outcome
• Thyroxine (therapeutic use)
• Treatment Outcome