Abstract |
Interaction between antigen presenting cells and T lymphocytes, through receptors and co-stimulatory molecules present on the surface of these cells, is one of the key means to modulate the adaptive immune system. Tucaresol, a Schiff-base-forming chemical, can be used as a substitute for the physiological donor of carbonyl groups of antigen presenting cells, which can interact with the amine groups of T lymphocytes to modulate the adaptive immune system. This study was done to determine whether tucaresol can enhance killing of cancer cells in vitro as well as protect non-obese diabetic severe combined immunodeficient mice from tumor development by mucin 1 stimulated human mononuclear cells through the adaptive immune system. The expected hypothesis was not supported. Percent specific lysis of MCF-7 tumor cells by mucin 1 stimulated human mononuclear cells was reduced by tucaresol. Furthermore, tucaresol abolished the protective effect of mucin 1 stimulated human mononuclear cells against MCF-7 breast cancer cell growth in non-obese diabetic severe combined immunodeficient mice. This study implies that tucaresol may be of use as an immunosuppressive agent.
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Authors | Stephen E Wright, Kathleen A Rewers-Felkins, Nazrul I Chowdhury, Jewel Ahmed, Sanjay K Srivastava, Pamela R Lockwood-Cooke |
Journal | Immunological investigations
(Immunol Invest)
Vol. 43
Issue 2
Pg. 160-9
( 2014)
ISSN: 1532-4311 [Electronic] England |
PMID | 24303799
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Antigens, Neoplasm
- Benzaldehydes
- Benzoates
- Mucin-1
- tucaresol
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Topics |
- Adenocarcinoma
(immunology, therapy)
- Animals
- Antigen-Presenting Cells
(drug effects, immunology)
- Antigens, Neoplasm
(immunology)
- Benzaldehydes
(administration & dosage)
- Benzoates
(administration & dosage)
- Breast Neoplasms
(immunology, therapy)
- Cytotoxicity, Immunologic
(drug effects)
- Humans
- Immunological Synapses
(metabolism)
- Immunosuppression Therapy
- Leukocytes, Mononuclear
(immunology)
- Lymphocyte Activation
(drug effects)
- MCF-7 Cells
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Mucin-1
(immunology)
- Protein Carbonylation
- T-Lymphocytes
(immunology)
- Xenograft Model Antitumor Assays
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