Acadesine Triggers Non-apoptotic Death in Tumor Cells.

Abstract

We studied the cytotoxicity of acadesine (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) for tumor and normal cells of various species and tissue origin. In tumor cells, acadesine triggered non-apoptotic death; the potency of the compound to normal cells was substantially lower. Acadesine was toxic for tumor cells with multidrug resistant phenotypes caused by the transmembrane transporter Р-glycoprotein or lack of proapoptotic p53. Activity of adenosine receptors was required for acadesine-induced cell death, whereas functioning of АМР-dependent protein kinase was not required. A more pronounced cytotoxicity for tumor cells, as well as the non-canonical death mechanism(s), makes acadesine a promising candidate for antitumor therapy.

• Authors: V A Glazunova, K V Lobanov, R S Shakulov, A S Mironov, A A Shtil
• Journal: Acta naturae (Acta Naturae) Vol. 5 Issue 3 Pg. 74-8 (Jul 2013) ISSN: 2075-8251 [Print] Russia (Federation)
• PMID: 24303202 (Publication Type: Journal Article)