[The CD100 semaphorin expression on peripheral blood T-lymphocytes in patients with relapsing-remitting multiple sclerosis].

Abstract

The expression of CD100 semaphorin by the intact peripheral blood T lymphocytes in multiple sclerosis (MS) has been studied. The level of middle florescence intensity (MFI) and the number of B-lymphocytes bearing CD72 were evaluated. There were significant differences in the level of CD100 in patients compared to healthy volunteers. These data suggest the use of semaphorin as a possible therapeutic target in pathological inflammation in MS.

• Authors: T N Trushnikova, T V Baĭdina, I Iu Danchenko, E M Kuklina, I V Nekrasova
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 113 Issue 10 Pt 2 Pg. 47-51 ( 2013) ISSN: 1997-7298 [Print] Russia (Federation)
• PMID: 24300815 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antigens, CD
• Antigens, Differentiation, B-Lymphocyte
• CD100 antigen
• CD72 protein, human
• Semaphorins

Topics

• Adult
• Antigens, CD (biosynthesis, immunology)
• Antigens, Differentiation, B-Lymphocyte (immunology)
• Female
• Humans
• Immunity, Cellular
• Lymphocyte Activation
• Male
• Middle Aged
• Multiple Sclerosis, Relapsing-Remitting (blood, immunology)
• Semaphorins (biosynthesis, immunology)
• T-Lymphocytes (immunology)