HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Yeast ABC proteins involved in multidrug resistance.

Abstract
Pleiotropic drug resistance is a complex phenomenon that involves many proteins that together create a network. One of the common mechanisms of multidrug resistance in eukaryotic cells is the active efflux of a broad range of xenobiotics through ATP-binding cassette (ABC) transporters. Saccharomyces cerevisiae is often used as a model to study such activity because of the functional and structural similarities of its ABC transporters to mammalian ones. Numerous ABC transporters are found in humans and some are associated with the resistance of tumors to chemotherapeutics. Efflux pump modulators that change the activity of ABC proteins are the most promising candidate drugs to overcome such resistance. These modulators can be chemically synthesized or isolated from natural sources (e.g., plant alkaloids) and might also be used in the treatment of fungal infections. There are several generations of synthetic modulators that differ in specificity, toxicity and effectiveness, and are often used for other clinical effects.
AuthorsAgata Piecuch, Ewa Obłąk
JournalCellular & molecular biology letters (Cell Mol Biol Lett) Vol. 19 Issue 1 Pg. 1-22 (Mar 2014) ISSN: 1689-1392 [Electronic] England
PMID24297686 (Publication Type: Journal Article, Review)
Chemical References
  • ATP-Binding Cassette Transporters
  • Xenobiotics
Topics
  • ATP-Binding Cassette Transporters (genetics, metabolism)
  • Drug Resistance, Multiple (genetics)
  • Humans
  • Models, Genetic
  • Saccharomyces cerevisiae
  • Structural Homology, Protein
  • Xenobiotics (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: