Indirect immunofluorescence test for human Babesia microti infection: antigenic specificity.

An indirect immunofluorescence (IIF) test was performed with human sera to detect cross-reactivity of Babesia microti antibodies with other species of Babesia parasites, with other blood and tissue parasites, and with various tick-borne organisms. Antisera to B. microti cross reacted with other Babesia species, but at lower dilutions than with the homologous antigens, and occurred most often during the acute phase of the disease. Cross-reactions with antibodies to malaria, Colorado tick fever, and a variety of other parasitic diseases were uncommon. However, acute and convalescent phase sera from 4 patients with suspected or confirmed Rocky Mountain spotted fever showed a rise in titer to B. microti antigen. In addition, 6 of 185 serum samples from children on an Indian reservation in North Carolina had IIF titers of greater than or equal to 1:256, suggesting a possible focus of B. microti infections in humans.
AuthorsE S Chisholm, A J Sulzer, T K Ruebush 2nd
JournalThe American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 35 Issue 5 Pg. 921-5 (Sep 1986) ISSN: 0002-9637 [Print] UNITED STATES
PMID2429568 (Publication Type: Journal Article)
Chemical References
  • Antibodies
  • Antigens, Protozoan
  • Epitopes
  • Antibodies (analysis, immunology)
  • Antigens, Protozoan (immunology)
  • Babesia (immunology)
  • Babesiosis (diagnosis, immunology)
  • Cross Reactions
  • Epitopes
  • Fluorescent Antibody Technique
  • Humans
  • Malaria (immunology)
  • Plasmodium (immunology)

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