Abstract | OBJECTIVE: DESIGN: Prospective, parallel-arm randomised controlled trial with blinding of participants, care-givers and outcome assessors. SETTING: Maternity units in two District General Hospitals in the UK. POPULATION: After written informed consent, 484 women were randomised and recruited (244 diamorphine, 240 pethidine). Inclusion criteria included women 16 years or older, established labour, singleton pregnancy, 37-42 weeks of gestation and weight 60-120 kg. METHODS: On request of i.m. analgesia, participants received either 150 mg pethidine or 7.5 mg diamorphine based on computer-generated block randomisation. MAIN OUTCOME MEASURES: Maternal-reduction in pain intensity from baseline (10-cm visual analogue scale) at 60 minutes and over the 3-hour period after drug administration. Neonatal-requirement for resuscitation and Apgar score at 1 minute. RESULTS:
Diamorphine provided modestly improved pain relief at 60 minutes, mean difference 1 cm (95% confidence interval [CI] 0.5-1.5), and over the 3 hours, mean difference 0.7 cm (95% CI 0.3-1.1). However, average length of labour in women receiving diamorphine was 82 minutes longer (95% CI 39-124) and therefore they experienced more pain overall. There were no statistically significant differences in primary neonatal outcomes. CONCLUSIONS:
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Authors | M Y K Wee, J P Tuckey, P W Thomas, S Burnard |
Journal | BJOG : an international journal of obstetrics and gynaecology
(BJOG)
Vol. 121
Issue 4
Pg. 447-56
(Mar 2014)
ISSN: 1471-0528 [Electronic] England |
PMID | 24289216
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 Royal College of Obstetricians and Gynaecologists. |
Chemical References |
- Analgesics, Opioid
- Heroin
- Meperidine
|
Topics |
- Adolescent
- Adult
- Analgesia, Obstetrical
(methods)
- Analgesics, Opioid
(therapeutic use)
- Double-Blind Method
- Drug Administration Schedule
- Female
- Heroin
(therapeutic use)
- Humans
- Injections, Intramuscular
- Labor Pain
(drug therapy)
- Logistic Models
- Meperidine
(therapeutic use)
- Pain Measurement
- Pregnancy
- Prospective Studies
- Treatment Outcome
- Young Adult
|