Abstract | BACKGROUND: Overexpression of IL-23 has been implicated in the pathogenesis of Crohn's disease. Using vaccines to block overexpressed endogenous cytokines has emerged as a new therapeutic strategy for the long-term treatment of the disease. AIM: MATERIALS & METHODS: RESULTS: In vitro studies revealed that serum IL-23 p19-specific IgG significantly suppressed IL-23-induced IL-17 production by splenocytes. In vivo evaluation of the effect of the vaccine in mice with chronic colitis indicated that vaccine-immunized mice exhibited a decrease in colon inflammation, collagen deposition and levels of IL-23 and IL-12 cytokines, compared with control groups. CONCLUSION:
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Authors | Qingdong Guan, Helen A Burtnick, Gefei Qing, Carolyn R Weiss, Allan G Ma, Yanbing Ma, Richard J Warrington, Zhikang Peng |
Journal | Immunotherapy
(Immunotherapy)
Vol. 5
Issue 12
Pg. 1313-22
(Dec 2013)
ISSN: 1750-7448 [Electronic] England |
PMID | 24283842
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immunoglobulin G
- Interleukin-17
- Interleukin-23
- Interleukin-23 Subunit p19
- Peptides
- Vaccines, Subunit
- Interleukin-12
- Trinitrobenzenesulfonic Acid
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Topics |
- Amino Acid Sequence
- Animals
- Cells, Cultured
- Chronic Disease
- Colitis
(chemically induced, immunology, prevention & control)
- Colon
(immunology, metabolism, pathology)
- Down-Regulation
(immunology)
- Enzyme-Linked Immunosorbent Assay
- Female
- Immunoglobulin G
(blood, immunology)
- Interleukin-12
(immunology, metabolism)
- Interleukin-17
(immunology, metabolism)
- Interleukin-23
(immunology, metabolism)
- Interleukin-23 Subunit p19
(immunology)
- Mice
- Mice, Inbred BALB C
- Peptides
(administration & dosage, immunology)
- Spleen
(cytology, immunology, metabolism)
- Trinitrobenzenesulfonic Acid
- Vaccination
(methods)
- Vaccines, Subunit
(administration & dosage, immunology)
- Weight Loss
(immunology)
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