Ovarian granulosa cell tumor and increased risk of breast cancer.

Abstract

Granulosa cell tumor of the ovary (GCT) is a rare neoplasm. The tumor often secretes estrogens and then presents at an earlier stage due to hormone-related symptoms. GCT women are at increased risk of endometrial carcinoma, but there is only limited information about GCTs and potential association to other hormone-related neoplasms such as breast cancer. We conducted a retrospective follow-up study on 163 women with GCT. Medical records and histological sections were reviewed and a search in the pathology registry performed. Eight [95% confidence interval (CI); 3.4-15.8] GCT women were diagnosed with a breast neoplasm; one with Paget's disease of the nipple and seven with breast carcinoma. Based on calculations using incidence rates on breast cancer among Danish women, we would have expected 2.5 cases of breast cancer. The odds ratio was 3.3 (95% CI, 1.6-6.6), suggesting an increased risk of breast cancer in GCT women.

• Authors: Anne Hammer, Finn F Lauszus, Astrid C Petersen
• Journal: Acta obstetricia et gynecologica Scandinavica (Acta Obstet Gynecol Scand) Vol. 92 Issue 12 Pg. 1422-5 (Dec 2013) ISSN: 1600-0412 [Electronic] United States
• PMID: 24283356 (Publication Type: Journal Article)
• Copyright: © 2013 Nordic Federation of Societies of Obstetrics and Gynecology.

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Breast Neoplasms (epidemiology, etiology)
• Denmark (epidemiology)
• Female
• Granulosa Cell Tumor (complications)
• Humans
• Incidence
• Middle Aged
• Odds Ratio
• Ovarian Neoplasms (complications)
• Retrospective Studies