[Efficacy of combined 5-nitroimidazole and probiotic therapy of bacterial vaginosis: randomized open trial].

Abstract

UNLABELLED:

The aim of the current research is to identify the clinical and microbiological effect of 5-nitroimidazol therapy for the treatment of bacterial vaginosis and in combination with probiotics and the influence of such therapy upon vaginal flora.

MATERIALS AND METHODS:

Women (n = 539) with bacterial vaginosis who meet the criteria were included in the study. They were randomized into two groups with the following therapeutic regimes: in the first group (n = 242 women) the treatment included applications of 2g BID tinidazole for two days and vaginal suppositories of 1000 mg metronidazol at day 1 and 3 (T+M). In the second group (n = 297) the women were cured with the same treatment as those in the first group. In addition to it from the fifth day of the treatment was added a topical administration of vaginal probiotic which contains species of alive lactobacilli: Lactobacillus acidophilus, Lactobacillus rhamnosus (T+M+P). The efficacy from the therapy was evaluated using the clinical compliances of the women, the data from the clinical examination and the microbiological tests results.

RESULTS:

The results showed expected increase of clinical therapy efficacy (Amsel - criteria) from 42.8% (T+M; n = 211/242) to 84.06% (T+M+P; n = 274/297) in groups and of microbiological efficacy (Nugent) from 44.7% (T+M; n = 211/242) to 83.3% (T+M+P; n = 274/297), in follow up 35-40 days from the beginning of treatment. The percentage of women with normal vaginal flora on 35-40 day after the therapy increase with 57% in the (T+M) first group while in the second group (T+M+P) with 94%.

CONCLUSIONS:

Combining the therapies of 5-nitroimidazoles and vaginal probiotic reduce bacterial vaginosis recurrence and restores permanently normal vaginal flora.

• Authors: S Kovachev, R Vatcheva-Dobrevski
• Journal: Akusherstvo i ginekologiia (Akush Ginekol (Sofiia)) Vol. 52 Issue 3 Pg. 19-26 ( 2013) ISSN: 0324-0959 [Print] Bulgaria
• PMID: 24283058 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Infective Agents
• Nitroimidazoles
• Tinidazole
• Metronidazole
• 4-nitroimidazole

Topics

• Adolescent
• Adult
• Anti-Infective Agents (therapeutic use)
• Female
• Humans
• Lactobacillus acidophilus (physiology)
• Lacticaseibacillus rhamnosus (physiology)
• Metronidazole (therapeutic use)
• Middle Aged
• Nitroimidazoles (therapeutic use)
• Probiotics (therapeutic use)
• Tinidazole (therapeutic use)
• Vagina (microbiology)
• Vaginosis, Bacterial (drug therapy, microbiology)
• Young Adult