Effect of orally administered celiprolol in patients with chronic atrial fibrillation.

Abstract

The heart rate increase induced by dynamic exercise in patients with chronic atrial fibrillation is competitively attenuated by beta-blockade. The influence of oral celiprolol on exercise induced tachycardia was evaluated in 23 patients with chronic stable atrial fibrillation in a dose-titration study. This was succeeded by a placebo-controlled double-blind, crossover multi-center trial. During the dose-titration phase each patient underwent a single-blind three week dose escalation period-taking celiprolol 200 mg once daily for one week, celiprolol 400 mg once daily for the third week. After a one week placebo washout, patients then entered a double-blind crossover phase, consisting of one week each of placebo or celiprolol according to a pre-determined randomization. After one week of placebo washout, each patient was crossed-over. In 21 patients celiprolol reduces exercise-induced increased heart rate by approximately 35% when compared with placebo. These results indicate that celiprolol should be effective in controlling the exercise-induced increase in heart rate in patients with chronic atrial fibrillation. In addition, results of 24 h ambulatory ECG monitoring (Holtor monitoring) indicate that celiprolol reduces the ventricular premature contractions.

• Authors: S K Lin, J Morganroth, M Heng, S Rubler, W Baird, J E Atwood, N Mostow, O M Scarse, P Yu, F S Caruso
• Journal: Journal of cardiovascular pharmacology (J Cardiovasc Pharmacol) Vol. 8 Suppl 4 Pg. S112-5 ( 1986) ISSN: 0160-2446 [Print] United States
• PMID: 2427838 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Propanolamines
• Celiprolol

Topics

• Administration, Oral
• Aged
• Atrial Fibrillation (drug therapy)
• Celiprolol
• Clinical Trials as Topic
• Electrocardiography
• Exercise Test
• Female
• Humans
• Male
• Middle Aged
• Propanolamines (administration & dosage, therapeutic use)