Abstract | PURPOSE: METHODS: Patients diagnosed with a pituitary adenoma and treated with two or more courses of radiation treatment (RT) to the sella were retrospectively analyzed for: initial diagnosis, including histological type and functional status; RT modality, technique, dose, and fractionation; treatment with surgery, endocrine agents, and chemotherapy; toxicity of RT including radiation-induced optic neuropathy, radionecrosis, and radiation-induced neoplasms; and outcomes including local control, distant metastasis, biochemical control of functional tumors, and vital status at last follow-up. RESULTS: We identified 15 patients with non-functioning pituitary adenoma (n = 6), Cushing's disease (CD) (n = 5), acromegaly (n = 3), and prolactinoma (n = 1). Initial RT was delivered using opposed lateral fields in 8 (53%), intensity-modulated radiation therapy (IMRT) in 4 (27%), fractionated stereotactic radiation therapy (FSRT) in 1 (6.7%), and stereotactic radiosurgery (SRS) in 2. The median dose was 49.5 Gy for fractionated RT and 15-25 Gy for SRS. Re-irradiation was performed a median of 5.8 years after initial RT, and delivered using lateral opposed beams (n = 1), IMRT (n = 4), linear-accelerator based SRS (n = 3), FSRT (n = 3), gamma knife surgery (n = 2), and yttrium-90 brachytherapy (n = 1). The median dose of re-irradiation was 45 Gy (range 27.9-54 Gy) for fractionated RT and 18 Gy for SRS. Radiation-induced optic neuropathy (RION) was observed in 2 (13.3%) patients, 6 months and 14 years after re-irradiation; the 5-year rate of RION was 9 %. Temporal lobe necrosis (TLN) occurred in two patients (13.3%), both of whom had received SRS. The 2- and 5-year rates of TLN were 10 and 28%. Actuarial local control rates at 2 and 5 years were 80 and 58%, respectively. Biochemical remission occurred in one of three patients with CD. Four patients (27%) ultimately developed pituitary carcinoma. CONCLUSIONS:
Re-irradiation is a feasible treatment option for local control in patients with recalcitrant pituitary adenomas, with acceptable rates of RION and TLN given the lack of options that may be available otherwise. Re-irradiation, however, did not control hormonal hypersecretion.
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Authors | Jonathan Verma, Ian E McCutcheon, Steven G Waguespack, Anita Mahajan |
Journal | Pituitary
(Pituitary)
Vol. 17
Issue 6
Pg. 539-45
(Dec 2014)
ISSN: 1573-7403 [Electronic] United States |
PMID | 24272035
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Disease Progression
- Feasibility Studies
- Female
- Humans
- Male
- Middle Aged
- Necrosis
- Neoplasm Metastasis
(pathology)
- Neoplasm Recurrence, Local
(radiotherapy)
- Neoplasms, Radiation-Induced
(epidemiology)
- Optic Nerve Diseases
(etiology)
- Pituitary Function Tests
- Pituitary Neoplasms
(radiotherapy)
- Radiotherapy
(adverse effects, methods)
- Retrospective Studies
- Salvage Therapy
- Survival Analysis
- Treatment Outcome
- Young Adult
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