miR-181b promotes cell proliferation and reduces apoptosis by repressing the expression of adenylyl cyclase 9 (AC9) in cervical cancer cells.

Abstract

MicroRNAs are a class of small, endogenous, non-coding RNAs that function as post-transcriptional regulators. In this study, we found that miR-181b promoted cell proliferation and inhibited cell apoptosis in cervical cancer cells. And we validated a new miR-181b target gene, adenylyl cyclase 9 (AC9). miR-181b restricted cAMP production by post-transcriptionally downregulating AC9 expression. Phenotypic experiments indicated that miR-181b and AC9 exerted opposite effects on cell proliferation and apoptosis.

• Authors: Lei Yang, Yan-Li Wang, Shang Liu, Pei-Pei Zhang, Zheng Chen, Min Liu, Hua Tang
• Journal: FEBS letters (FEBS Lett) Vol. 588 Issue 1 Pg. 124-30 (Jan 03 2014) ISSN: 1873-3468 [Electronic] England
• PMID: 24269684 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Chemical References

• 3' Untranslated Regions
• MIrn181 microRNA, human
• MicroRNAs
• Oligonucleotides, Antisense
• Cyclic AMP
• Adenylyl Cyclases
• adenylate cyclase 9

Topics

• 3' Untranslated Regions (genetics)
• Adenylyl Cyclases (genetics, metabolism)
• Apoptosis (genetics)
• Base Sequence
• Binding Sites (genetics)
• Blotting, Western
• Cell Line, Tumor
• Cell Proliferation
• Cell Survival (genetics)
• Cyclic AMP (metabolism)
• Female
• Gene Expression Regulation, Neoplastic
• HeLa Cells
• Humans
• MicroRNAs (genetics, metabolism)
• Oligonucleotides, Antisense (genetics)
• RNA Interference
• Reverse Transcriptase Polymerase Chain Reaction
• Uterine Cervical Neoplasms (genetics, metabolism, pathology)