Abstract | BACKGROUND/PURPOSE: METHODS: We evaluated 116 AT patients with ultrasound-guided aspiration cytology and then analyzed the correlation between thyroid hormone status and thyroid autoantibodies. This was a retrospective analysis with prospective collection of data with a mean follow-up period of 68.8 ± 37.8 months. The patients were classified as either euthyroid, hypothyroid, or hyperthyroid (HT). Of the 116 patients, 22 were hypothyroid, 37 were euthyroid, and 57 were HT. RESULTS: During the follow-up period, 95.5% of the hypothyroid group remained hypothyroid and only one patient improved to euthyroid. In the euthyroid group, 16.2% progressed to hypothyroid and 83.8% remained euthyroid. In the HT group, 8.7% progressed to hypothyroid, 70.2% progressed to euthyroid, and 21.1% remained HT. Most patients with a high titer of thyroglobulin antibody (TgAb) will progress to hypothyroid, and patients with a high titer of thyroid stimulating hormone ( TSH) receptor antibody (TRAb) will remain HT. Strong correlations between thyroid functional status and positive number of thyroid autoantibodies were seen in this study. Patients with all the three antibodies positive had a high prevalence of hyperthyroidism. CONCLUSION: In our study, most patients were HT; this may be because of the early diagnosis and treatment of AT in our clinic. Although antithyroperoxidase antibody (TPOAb) is a hallmark antibody of HT, it cannot predict the initial presentation and clinical outcome.
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Authors | Kuei-Mei Chou, Bie-Yui Huang, Chih-Huang Chen, Jen-Der Lin, Sherry Yueh-Hsia Chiu, Chin-Chan Lee |
Journal | Journal of the Formosan Medical Association = Taiwan yi zhi
(J Formos Med Assoc)
Vol. 114
Issue 11
Pg. 1039-46
(Nov 2015)
ISSN: 0929-6646 [Print] Singapore |
PMID | 24269111
(Publication Type: Journal Article)
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Copyright | Copyright © 2013. Published by Elsevier B.V. |
Chemical References |
- Autoantibodies
- anti-thyroglobulin
- thyroid microsomal antibodies
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Topics |
- Adult
- Autoantibodies
(blood)
- Female
- Follow-Up Studies
- Humans
- Hyperthyroidism
(blood)
- Hypothyroidism
(blood)
- Male
- Middle Aged
- Retrospective Studies
- Thyroid Gland
(physiopathology)
- Thyroiditis, Autoimmune
(blood)
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