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Leptin promotes lupus T-cell autoimmunity.

Abstract
In systemic lupus erythematosus (SLE), the impairment in apoptosis can facilitate the initiation and maintenance of autoimmune responses to self antigens. Here we show that the adipocytokine leptin, which is abnormally elevated in SLE, promotes the survival and proliferation of autoreactive T-cells in mice with an autoreactive T-cell repertoire, including (NZB x NZW)F1 lupus-prone mice. This ability of leptin to promote lupus T-cell autoimmunity suggests the possibility of a therapeutic targeting of leptin in SLE.
AuthorsGil Amarilyo, Noriko Iikuni, Fu-Dong Shi, Aijing Liu, Giuseppe Matarese, Antonio La Cava
JournalClinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 149 Issue 3 Pg. 530-3 (Dec 2013) ISSN: 1521-7035 [Electronic] United States
PMID24263282 (Publication Type: Journal Article)
Copyright© 2013.
Chemical References
  • Autoantibodies
  • Leptin
  • Dexamethasone
Topics
  • Animals
  • Apoptosis (drug effects)
  • Autoantibodies (biosynthesis)
  • Autoimmunity (drug effects)
  • Cells, Cultured
  • Dexamethasone (pharmacology)
  • Leptin (pharmacology)
  • Lupus Erythematosus, Systemic (immunology, metabolism, pathology)
  • Lymphocyte Activation (drug effects)
  • Mice
  • Mice, Inbred NZB
  • Mice, Transgenic
  • Thymocytes (cytology, drug effects, immunology)

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