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Intravenous immunoglobulin preparation attenuates neurological signs in rat experimental autoimmune neuritis with the suppression of macrophage inflammatory protein -1α expression.

Abstract
To clarify the mechanism of action of an intravenous immunoglobulin (IVIG) preparation in chronic inflammatory demyelinating polyneuropathy, the effects of IVIG were investigated using an experimental autoimmune neuropathy model in the rat. IVIG significantly suppressed the progression of neurologic signs and sciatic nerve conduction velocity with the inhibition of inflammatory cell infiltration, mainly of macrophages, to the peripheral nerves. A significant suppressive effect on the expression of macrophage inflammatory protein 1-α (MIP-1α) was simultaneously observed in the nerves. These results suggest that IVIG is effective for inflammatory demyelinating polyneuropathy by inhibiting the chemotactic factor of macrophages.
AuthorsMasahiko Kajii, Fujio Kobayashi, Junichi Kashihara, Takashi Yuuki, Yoshiji Kubo, Takashi Nakae, Akihito Kamizono, Yoshimasa Kuzumoto, Susumu Kusunoki
JournalJournal of neuroimmunology (J Neuroimmunol) Vol. 266 Issue 1-2 Pg. 43-8 (Jan 15 2014) ISSN: 1872-8421 [Electronic] Netherlands
PMID24262701 (Publication Type: Journal Article)
CopyrightCopyright © 2013 Elsevier B.V. All rights reserved.
Chemical References
  • Aif1 protein, rat
  • CD3 Complex
  • Calcium-Binding Proteins
  • Chemokine CCL3
  • Chemokines
  • Immunoglobulins, Intravenous
  • Microfilament Proteins
  • RNA, Messenger
  • Freund's Adjuvant
Topics
  • Action Potentials (drug effects)
  • Animals
  • CD3 Complex
  • Calcium-Binding Proteins (metabolism)
  • Chemokine CCL3 (genetics, metabolism)
  • Chemokines (metabolism)
  • Disease Models, Animal
  • Freund's Adjuvant (toxicity)
  • Immunoglobulins, Intravenous (therapeutic use)
  • Male
  • Microfilament Proteins (metabolism)
  • Myelin Sheath (pathology)
  • Neural Conduction (drug effects)
  • Neuritis, Autoimmune, Experimental (drug therapy, pathology, physiopathology)
  • RNA, Messenger (metabolism)
  • Rats
  • Rats, Inbred Lew
  • Reaction Time (drug effects)
  • Sciatic Nerve (drug effects, metabolism, physiopathology)
  • Time Factors

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