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Preventive inositol hexaphosphate extracted from rice bran inhibits colorectal cancer through involvement of Wnt/β-catenin and COX-2 pathways.

Abstract
Nutritional or dietary factors have drawn attention due to their potential as an effective chemopreventive agent, which is considered a more rational strategy in cancer treatment. This study was designed to evaluate the effect of IP₆ extracted from rice bran on azoxymethane- (AOM-) induced colorectal cancer (CRC) in rats. Initially, male Sprague Dawley rats were divided into 5 groups, with 6 rats in each group. The rats received two intraperitoneal (i.p.) injections of AOM in saline (15 mg/kg body weight) over a 2-week period to induce CRC. IP₆ was given in three concentrations, 0.2% (w/v), 0.5% (w/v), and 1.0% (w/v), via drinking water for 16 weeks. The deregulation of the Wnt/β-catenin signaling pathway and the expression of cyclooxygenase (COX)-2 have been implicated in colorectal tumorigenesis. β-Catenin and COX-2 expressions were analysed using the quantitative RT-PCR and Western blotting. Herein, we reported that the administration of IP₆ markedly suppressed the incidence of tumors when compared to the control. Interestingly, the administration of IP₆ had also markedly decreased β-catenin and COX-2 in colon tumors. Thus, the downregulation of β-catenin and COX-2 could play a role in inhibiting the CRC development induced by IP₆ and thereby act as a potent anticancer agent.
AuthorsNurul Husna Shafie, Norhaizan Mohd Esa, Hairuszah Ithnin, Abdah Md Akim, Norazalina Saad, Ashok Kumar Pandurangan
JournalBioMed research international (Biomed Res Int) Vol. 2013 Pg. 681027 ( 2013) ISSN: 2314-6141 [Electronic] United States
PMID24260743 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Dietary Fiber
  • Neoplasm Proteins
  • beta Catenin
  • Phytic Acid
  • Cyclooxygenase 2
  • Ptgs2 protein, rat
Topics
  • Animals
  • Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
  • Colorectal Neoplasms (chemically induced, metabolism, pathology, prevention & control)
  • Cyclooxygenase 2 (metabolism)
  • Dietary Fiber
  • Male
  • Neoplasm Proteins (antagonists & inhibitors, metabolism)
  • Neoplasms, Experimental (chemically induced, metabolism, prevention & control)
  • Oryza (chemistry)
  • Phytic Acid (chemistry, isolation & purification, pharmacology)
  • Rats
  • Rats, Sprague-Dawley
  • Wnt Signaling Pathway (drug effects)
  • beta Catenin (metabolism)

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