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Assessing the susceptibility of transgenic mice overexpressing deer prion protein to bovine spongiform encephalopathy.

Abstract
Several transgenic mouse models have been developed which facilitate the transmission of chronic wasting disease (CWD) of cervids and allow prion strain discrimination. The present study was designed to assess the susceptibility of the prototypic mouse line, Tg(CerPrP)1536(+/-), to bovine spongiform encephalopathy (BSE) prions, which have the ability to overcome species barriers. Tg(CerPrP)1536(+/-) mice challenged with red deer-adapted BSE resulted in 90% to 100% attack rates, and BSE from cattle failed to transmit, indicating agent adaptation in the deer.
AuthorsChristopher M Vickery, Richard Lockey, Thomas M Holder, Leigh Thorne, Katy E Beck, Christina Wilson, Margaret Denyer, John Sheehan, Sarah Marsh, Paul R Webb, Ian Dexter, Angela Norman, Emma Popescu, Amanda Schneider, Paul Holden, Peter C Griffiths, Jane M Plater, Mark P Dagleish, Stuart Martin, Glenn C Telling, Marion M Simmons, John Spiropoulos
JournalJournal of virology (J Virol) Vol. 88 Issue 3 Pg. 1830-3 (Feb 2014) ISSN: 1098-5514 [Electronic] United States
PMID24257620 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Prions
Topics
  • Animals
  • Cattle
  • Central Nervous System (metabolism, pathology)
  • Deer (metabolism)
  • Disease Models, Animal
  • Disease Susceptibility
  • Encephalopathy, Bovine Spongiform (metabolism, pathology, transmission)
  • Female
  • Male
  • Mice
  • Mice, Transgenic
  • Prions (metabolism)
  • Species Specificity
  • Wasting Disease, Chronic (metabolism, pathology, transmission)

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