Abstract | OBJECTIVES: DESIGN: Fifty-nine female patients with IBS age 18-65 years diagnosed by TCM practitioners as showing primarily an excess (n=32) or an overlap (n=27) pattern (mixed excess and deficiency) were assessed for symptom differences, heart rate, and skin conductance responses to a psychosocial stressor and pain perception. SETTINGS/LOCATIONS: University of California in Los Angeles, California. RESULTS: Compared with the excess group, the overlap group showed significantly greater overall gastrointestinal symptom severity, abdominal pain, and negative affect. The excess group with higher levels of negative affect showed greater reactivity to stress, whereas the overlap group showed an opposite response pattern. The overlap group showed increased cold sensitivity. CONCLUSIONS: IBS patients with the overlap pattern have greater disease severity and comorbidity than those with excess alone. Those with excess showed a pattern of increased stress response with greater negative affect, whereas the overlap group with greater deficiency showed lower physiologic arousal with greater negative affect, consistent with depletion resulting from allostatic load.
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Authors | Megan C Chang, David Shapiro, Aditi Joshi, Leila Shahabi, Steven Tan, Suzanne Smith, Ka Kit Hui, Kirsten Tillisch, Emeran A Mayer, Bruce D Naliboff |
Journal | Journal of alternative and complementary medicine (New York, N.Y.)
(J Altern Complement Med)
Vol. 20
Issue 4
Pg. 276-83
(Apr 2014)
ISSN: 1557-7708 [Electronic] United States |
PMID | 24256027
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Topics |
- Adolescent
- Adult
- Aged
- Female
- Galvanic Skin Response
(physiology)
- Heart Rate
(physiology)
- Humans
- Irritable Bowel Syndrome
(classification, physiopathology, psychology)
- Los Angeles
- Medicine, Chinese Traditional
- Middle Aged
- Stress, Physiological
(physiology)
- Stress, Psychological
(physiopathology)
- Young Adult
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