Abstract | PURPOSE: The combination of docetaxel and S-1 (DS) therapy is effective in patients with unresectable gastric cancer and is expected to be a regimen in neoadjuvant setting for advanced gastric cancer. This study was held to evaluate the efficacy and safety of DS followed by surgery. METHODS: Patients with resectable gastric cancer received 2 courses of docetaxel 40 mg/m(2) on days 1, 15 and S-1 40 mg/m(2) bid orally on days 1-7, 15-21 every 4 weeks, followed by standard radical gastrectomy. Primary end point was the pathological response rate: rate of tumors in which one-third or more parts were affected. RESULTS: Fourteen patients were enrolled. Thirteen (92.8 %) patients completed two courses of chemotherapy. Grade 3 adverse events were neutropenia in 3 (21.4 %) patients, anemia in 1 (6.2 %) patient and diarrhea in 1 (6.2 %) patient. There were no grade 4 adverse event and febrile neutropenia. All patients underwent R0 resection, and pathological response was found in 50.0 % of patients. There were no major surgical complications and no treatment-related mortality. CONCLUSIONS: The neoadjuvant chemotherapy with DS was effective for patients with locally advanced gastric cancer with manageable toxicities. Further study to confirm the usefulness of this regimen is needed.
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Authors | Takashi Kosaka, Hirotoshi Akiyama, Hirochika Makino, Ryo Takagawa, Jun Kimura, Hidetaka Ono, Chikara Kunisaki, Itaru Endo |
Journal | Cancer chemotherapy and pharmacology
(Cancer Chemother Pharmacol)
Vol. 73
Issue 2
Pg. 281-5
(Feb 2014)
ISSN: 1432-0843 [Electronic] Germany |
PMID | 24253176
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Drug Combinations
- Taxoids
- S 1 (combination)
- Tegafur
- Docetaxel
- Oxonic Acid
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Topics |
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Cohort Studies
- Docetaxel
- Drug Combinations
- Feasibility Studies
- Female
- Humans
- Male
- Middle Aged
- Neoadjuvant Therapy
- Neoplasm Staging
- Oxonic Acid
(administration & dosage)
- Prospective Studies
- Stomach Neoplasms
(drug therapy, pathology, surgery)
- Taxoids
(administration & dosage)
- Tegafur
(administration & dosage)
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