Abstract | INTRODUCTION: METHODS: In a randomized clinical trial, sixty patients undergoing open cholecystectomy were randomized into two groups. Before anesthesia induction, Diclofenac suppository (100 mg) and oral Clonidine (0.2 mg) were administered in the first group. Immediately before operation, patients received Ketamine (1 mg/kg IV) while the control group received placebo. The site of incision was infiltrated by the surgeon with 20 mL Bupivacaine 0.25% in both groups. Anesthesia induction and maintenance were similar in both groups. The severity of pain was recorded 2, 4, 6, 12, 24 and 48 hours after operation according to Visual Analogue Scale. RESULTS: The severity of pain at two defined stages (6 and 12 hours later) was significantly less in the intervention group than the control group (P<0.005). The average pain severity score was less than the control group (P<0.005). CONCLUSION:
|
Authors | Dawood Aghamohammadi, Hamzeh Hosseinzadeh, Mahmood Eidy, Zahra Mohammadzadeh Vizhe, Mohammad Bassir Abolghasemi Fakhri, Reza Movassaghi, Kamyar Ghabili, Samad Ej Golzari |
Journal | Journal of cardiovascular and thoracic research
(J Cardiovasc Thorac Res)
Vol. 4
Issue 3
Pg. 65-8
( 2012)
ISSN: 2008-5117 [Print] Iran |
PMID | 24250987
(Publication Type: Journal Article)
|