Abstract | INTRODUCTION: METHODS: In Double blind clinical trial study in Tabriz University of medical science, 50 patients candidate to CABG randomly divided in two groups and matched together according to sex, age and NYHA class. In intervention group after surgery and before the opening of the aortic clamping solution warm blood containing citrate phosphate dextrose (CPD; 3cc/100cc), value (100cc/min/m2BSA) for three minutes was administered. In control group, only pure blood administered. Oxidative stress markers measured in five stages and cardiac enzymes measured in three stages of surgery. RESULTS: Mean age 62.3±9.1 years including 30(60%) men and 20(40%) women. Ejection fractions between two groups were not significant before and after treatment. Administration of CPD was not significant effects on cardiac enzyme. Measurement of oxidative stress in different time were not different in malonil dialdehyde, superoxide dismutase and GPx but total antioxidant status were improved after intervention in compared with control group (p<0.001). CONCLUSION: Results showed that CPD were positive effects of increasing in total antioxidant status after CABG, but in reduction of other oxidative markers were unlabeled.
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Authors | Alireza Yaghoubi, Saeid Danaee, Shahin Imani, Mohammadali Sheikhalizadeh, Morteza Ghojazadeh |
Journal | Journal of cardiovascular and thoracic research
(J Cardiovasc Thorac Res)
Vol. 3
Issue 4
Pg. 123-7
( 2011)
ISSN: 2008-5117 [Print] Iran |
PMID | 24250969
(Publication Type: Journal Article)
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