High dose bystander effects in spatially fractionated radiation therapy.

Abstract

Traditional radiotherapy of bulky tumors has certain limitations. Spatially fractionated radiation therapy (GRID) and intensity modulated radiotherapy (IMRT) are examples of advanced modulated beam therapies that help in significant reductions in normal tissue damage. GRID refers to the delivery of a single high dose of radiation to a large treatment area that is divided into several smaller fields, while IMRT allows improved dose conformity to the tumor target compared to conventional three-dimensional conformal radiotherapy. In this review, we consider spatially fractionated radiotherapy approaches focusing on GRID and IMRT, and present complementary evidence from different studies which support the role of radiation induced signaling effects in the overall radiobiological rationale for these treatments.

• Authors: Rajalakshmi Asur, Karl T Butterworth, Jose A Penagaricano, Kevin M Prise, Robert J Griffin
• Journal: Cancer letters (Cancer Lett) Vol. 356 Issue 1 Pg. 52-7 (Jan 01 2015) ISSN: 1872-7980 [Electronic] Ireland
• PMID: 24246848 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Reactive Oxygen Species

Topics

• Animals
• Bystander Effect (radiation effects)
• DNA Damage (radiation effects)
• Dose Fractionation, Radiation
• Humans
• Mice
• Neoplasms (radiotherapy)
• Radiotherapy, Intensity-Modulated (adverse effects)
• Reactive Oxygen Species (metabolism)
• Signal Transduction (radiation effects)