[Regulation of aldosterone secretion in thyrotoxicosis. Thyroid hormones as possible stimulators of the activity of the renin-angiotensin-aldosterone system].

Abstract

A study was made of function of the renin-angiotensin-aldosterone system in patients with diffuse tosic goiter before and after treatment with thyrostatic and thyroid drugs respectively. Diffuse toxic goiter was shown to be accompanied by the development of hyperreninemic hyperaldosteronism, and in hypothyrosis hypoaldosteronism developed in the presence of raised activity of plasma renin. A tendency to return of aldosterone indices in both groups of patients to normal was noted in the time course of appropriate therapy. Possible mechanisms of the observed phenomena were discussed.

• Authors: E S Rom-Bugoslavskaia, I V Komarova
• Journal: Problemy endokrinologii (Probl Endokrinol (Mosk)) 1986 Mar-Apr Vol. 32 Issue 2 Pg. 13-6 ISSN: 0375-9660 [Print] Russia (Federation)
• Vernacular Title: Reguliatsiia sekretsii al'dosterona u bol'nykh tireotoksikozom. Tireoidnye gormony kak vozmozhnye stimuliatory aktivnosti sistemy renin-angiotenzin-al'dosteron.
• PMID: 2424003 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antithyroid Agents
• Thyroid Hormones
• aldosterone 18-glucuronide
• Aldosterone
• thyroidin
• Renin

Topics

• Aldosterone (analogs & derivatives, blood, urine)
• Antithyroid Agents (therapeutic use)
• Female
• Humans
• Hyperthyroidism (physiopathology)
• Hypothyroidism (drug therapy)
• Male
• Renin (blood)
• Renin-Angiotensin System
• Thyroid Hormones (physiology, therapeutic use)