Lung transplantation in children. Specific aspects.

Abstract

Lung transplantation has become in recent years a therapeutic option for infantswith terminal lung disease with similar results to transplantation in adults.In Spain, since 1996 114 children lung transplants have been performed; this corresponds to3.9% of the total transplant number.The most common indication in children is cystic fibrosis, which represents between 70-80% of the transplants performed in adolescents. In infants common indications areinterstitial lung disease and pulmonary hypertension.In most children a sequential double lung transplant is performed, generally with the help ofextracorporeal circulation. Lung transplantation in children presents special challenges in monitoring and follow-up, especially in infants, given the difficulty in assessing lung function and performing transbronchial biopsies.There are some more specific complications in children like postransplant lymphoproliferative syndrome or a greater severity of respiratory virus infections .After lung transplantation children usually experiment a very important improvement in their quality of life. Eighty eight per cent of children have no limitations in their activity after 3 years of transplantation.According to the registry of the International Society for Heart & Lung Transplantation (ISHLT) survival at 5 years of transplantation is 54% and at 10 years is around 35%.

• Authors: Antonio Moreno Galdó, Juan Solé Montserrat, Antonio Roman Broto
• Journal: Archivos de bronconeumologia (Arch Bronconeumol) Vol. 49 Issue 12 Pg. 523-8 (Dec 2013) ISSN: 1579-2129 [Electronic] Spain
• PMID: 24239132 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2013 SEPAR. Published by Elsevier Espana. All rights reserved.

Chemical References

• Immunosuppressive Agents

Topics

• Adolescent
• Child
• Child, Preschool
• Contraindications
• Cystic Fibrosis (surgery)
• Epstein-Barr Virus Infections (complications)
• Extracorporeal Circulation
• Graft Rejection (prevention & control)
• Graft vs Host Disease (prevention & control)
• Humans
• Hypertension, Pulmonary (surgery)
• Immunosuppressive Agents (therapeutic use)
• Infant
• Lung Diseases, Interstitial (surgery)
• Lung Transplantation (methods, statistics & numerical data)
• Lymphoproliferative Disorders (epidemiology, etiology, virology)
• Organ Size
• Pneumonia, Viral (epidemiology, prevention & control)
• Postoperative Complications (epidemiology)
• Prognosis
• Referral and Consultation
• Spain
• Survival Rate
• Tissue Donors
• Tissue and Organ Procurement