Hypervolemic treatment of the chronic obliterative arteriopathies of extremities.

Abstract

The efficacy of dextran therapy in forty patients with chronic occlusive arterial disease (twelve with Buerger's disease and twenty-eight with atherosclerosis obliterans) was studied by repeated measurements of the following hemodynamic parameters;: the relative walking distance (RWD), the absolute walking distance (AWD), the oscillometric index (OI), the perfusion pressure of the affected limb (PP) and the Doppler index (DI) - the last two being determined by using an ultrasound technique. The hemodynamic improvements secondary to dextran therapy were demonstrated by the increase of RWD (from 115.3 m to 235.0 m), of AWD (from 170.4 m to 339.0 m), of PP (from 64.6 +/- 12.4 mmHg to 97.6 +/- 13.3 mmHg) and of DI (from 0.38 to 0.65). These results constitute strong arguments for the wider application of dextran therapy in the comprehensive management of chronic occlusive arterial disease.

• Authors: Z Brassai, P Koválszki, G H Pop, K Kiss, E Olosz
• Journal: Medecine interne (Med Interne) 1986 Jan-Mar Vol. 24 Issue 1 Pg. 37-41 ISSN: 0377-1202 [Print] Romania
• PMID: 2422732 (Publication Type: Journal Article)

Chemical References

• Dextrans

Topics

• Arteriosclerosis Obliterans (drug therapy, physiopathology)
• Chronic Disease
• Dextrans (therapeutic use)
• Humans
• Leg (blood supply)
• Locomotion (drug effects)
• Oscillometry
• Regional Blood Flow (drug effects)
• Thromboangiitis Obliterans (drug therapy, physiopathology)
• Ultrasonography