Abstract | BACKGROUND: OBJECTIVES: This review examined randomized controlled trials of progestin-only pills for differences in efficacy, acceptability, and continuation rates. SEARCH METHODS: Through October 2013, we searched the computerized databases MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), POPLINE, and LILACS for studies of progestin-only pills. We also searched for current trials via ClinicalTrials.gov and ICTRP. Previous searches also included EMBASE. SELECTION CRITERIA: DATA COLLECTION AND ANALYSIS: The first author abstracted the data and entered the information into RevMan 5. Another author performed a second, independent data abstraction to verify the initial data entry.We attempted to extract life-table rates (actuarial or continuous) and used the rate difference as the effect measure. Where life-table rates were not published, we used the incidence rate ratio (ratio of Pearl rates). Where only the crude number of events was published, we calculated the Peto odds ratio with 95% confidence interval (CI) using a fixed-effect model. For continuous variables, the mean difference (MD) was computed with 95% CI. Because of disparate exposures, we were not able to combine studies in meta-analysis. MAIN RESULTS: AUTHORS' CONCLUSIONS:
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Authors | David A Grimes, Laureen M Lopez, Paul A O'Brien, Elizabeth G Raymond |
Journal | The Cochrane database of systematic reviews
(Cochrane Database Syst Rev)
Issue 11
Pg. CD007541
(Nov 13 2013)
ISSN: 1469-493X [Electronic] England |
PMID | 24226383
(Publication Type: Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Review, Systematic Review)
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Chemical References |
- Contraceptives, Oral, Combined
- Contraceptives, Oral, Hormonal
- Progestins
- Levonorgestrel
- Ethynodiol Diacetate
- Desogestrel
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Topics |
- Contraceptives, Oral, Combined
(administration & dosage)
- Contraceptives, Oral, Hormonal
(administration & dosage, adverse effects)
- Desogestrel
(administration & dosage, adverse effects)
- Ethynodiol Diacetate
(administration & dosage)
- Female
- Humans
- Levonorgestrel
(administration & dosage)
- Progestins
(administration & dosage, adverse effects)
- Randomized Controlled Trials as Topic
- Uterine Hemorrhage
(chemically induced)
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