Lymphoma as a second malignancy in a patient with neuroendocrine tumor: mimicking dedifferentiation on dual-tracer PET/CT with 68Ga-DOTANOC and 18F-FDG.

Abstract

Neuroendocrine tumors (NETs) are rare tumors which express somatostatin receptors (SSTRs). We here present a case of a 50-year-old female patient with metastatic bronchial carcinoid. She underwent 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT which suggested a diagnosis of poorly differentiated NET. Biopsy of the lesion, however, revealed a second malignancy in the form of diffuse large B-cell lymphoma. Thus, very rarely, other primary tumors can mimic NETs on dual-tracer PET/CT, and biopsy is advised in doubtful cases.

• Authors: Sachin Jain, Punit Sharma, Varun Singh Dhull, Chandrasekhar Bal, Rakesh Kumar
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 39 Issue 4 Pg. 358-9 (Apr 2014) ISSN: 1536-0229 [Electronic] United States
• PMID: 24217543 (Publication Type: Case Reports, Journal Article)

Chemical References

• 68Ga-DOTANOC
• Organometallic Compounds
• Fluorodeoxyglucose F18

Topics

• Cell Dedifferentiation
• Diagnosis, Differential
• Female
• Fluorodeoxyglucose F18
• Humans
• Lymphoma, Large B-Cell, Diffuse (diagnosis, diagnostic imaging)
• Middle Aged
• Multimodal Imaging
• Neoplasms, Second Primary (diagnosis, diagnostic imaging)
• Neuroendocrine Tumors (pathology)
• Organometallic Compounds
• Positron-Emission Tomography
• Tomography, X-Ray Computed