Prostate cancer is a very common and highly unpredictable form of
cancer. Whereas many
prostate cancers are slow growing and could be left without treatment, others are very aggressive. Additionally, today there is no curative treatment for
prostate cancer patients with local or distant
metastasis. Identification of new, improved prognostic and diagnostic
biomarkers for
prostate cancer and the finding of better treatment strategies for metastatic
prostate cancer is therefore highly warranted. Interactions between epithelium and stroma are known to be important already during prostate development and this interplay is critical also in development, progression of primary
tumors and growth of
metastases. It is therefore reasonable to expect that future
biomarkers and therapeutic targets can be identified in the prostate
tumor and
metastasis stroma and this possibility should be further explored.