Clinical evaluation of photodynamic therapy efficacy in the treatment of oral leukoplakia.

Abstract

BACKGROUND:

The aim of the study was clinical evaluation of photodynamic therapy efficacy in the treatment of oral leukoplakia lesions.

METHODS:

Twenty-three consecutive patients aged 21-79 were included to the study. In all patients 44 homogeneous, flat leukoplakia lesions were clinically diagnosed and confirmed histopathologically. Photodynamic therapy was performed with the use of Photolon(®) photosensitizer, containing 20% Chlorine-e6 and 10% dimethyl sulfoxide and a semiconductor laser, with power up to 300mW and a wavelength of 660nm. Ten illumination sessions were conducted with the use of superficial light energy density of 90J/cm(2).

RESULTS:

At baseline the mean size of leukoplakia lesion was 6.5±5.10cm(2) while after photodynamic therapy 3±2.99cm(2). Significant reduction (on average by 53.8%) of leukoplakia lesions sizes was observed after therapy. Twelve (27.27%) lesions had been completely cured, 22 (50%) partially cured, although 10 (22.73%) lasted unchanged. The efficacy of PTD was comparable in women and men irrespective of age. There have been no adverse site effects during therapy noted.

CONCLUSIONS:

Within the limits of the study it can be concluded that photodynamic therapy with the use of Chlorine-e6 can lead to considerable reduction of oral leukoplakia lesions size thus may be useful in clinical practice. However there is a need of further studies on larger number of cases and longer follow-up time.

• Authors: Małgorzata Pietruska, Stefan Sobaniec, Piotr Bernaczyk, Magdalena Cholewa, Jan Krzysztof Pietruski, Ewa Dolińska, Anna Skurska, Ewa Duraj, Grażyna Tokajuk
• Journal: Photodiagnosis and photodynamic therapy (Photodiagnosis Photodyn Ther) Vol. 11 Issue 1 Pg. 34-40 (Mar 2014) ISSN: 1873-1597 [Electronic] Netherlands
• PMID: 24211597 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier B.V. All rights reserved.

Chemical References

• Chlorophyllides
• Porphyrins
• Radiation-Sensitizing Agents
• phytochlorin
• Dimethyl Sulfoxide

Topics

• Adult
• Chlorophyllides
• Dimethyl Sulfoxide (therapeutic use)
• Female
• Humans
• Lasers, Semiconductor
• Leukoplakia, Oral (radiotherapy)
• Low-Level Light Therapy (methods)
• Male
• Middle Aged
• Porphyrins (therapeutic use)
• Radiation-Sensitizing Agents (therapeutic use)