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Gastric diffuse large B cell lymphoma presenting as paraneoplastic cerebellar degeneration: case report and review of literature.

Abstract
Paraneoplastic cerebellar degeneration (PCD) is a type of paraneoplastic neurological disorder (PND) that is associated with many solid tumors, Hodgkin's lymphoma (HL) and very rarely with non-Hodgkin's lymphoma (NHL). We report a case of PCD associated with gastric diffuse large B-cell lymphoma (DLBCL) in a patient who presented with acute onset of giddiness and double vision and had complete remission of the gastric lesion and marked improvement of cerebellar syndrome with rituximab-based combination chemotherapy. A brief review of the literature is also presented.
AuthorsK C Lakshmaiah, B K Viveka, N Anil Kumar, Monika L Saini, Sanjib Sinha, Kamal S Saini
JournalJournal of the Egyptian National Cancer Institute (J Egypt Natl Canc Inst) Vol. 25 Issue 4 Pg. 231-5 (Dec 2013) ISSN: 2589-0409 [Electronic] England
PMID24207096 (Publication Type: Case Reports, Journal Article, Review)
CopyrightCopyright © 2013. Production and hosting by Elsevier B.V.
Chemical References
  • Antibodies, Monoclonal, Murine-Derived
  • R-CHOP protocol
  • Rituximab
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone
Topics
  • Antibodies, Monoclonal, Murine-Derived (therapeutic use)
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Biopsy
  • Cyclophosphamide (therapeutic use)
  • Diagnosis, Differential
  • Doxorubicin (therapeutic use)
  • Gastroscopes
  • Humans
  • Lymphoma, Large B-Cell, Diffuse (diagnosis, drug therapy)
  • Male
  • Middle Aged
  • Paraneoplastic Cerebellar Degeneration (diagnosis)
  • Positron-Emission Tomography
  • Prednisone (therapeutic use)
  • Rituximab
  • Stomach Neoplasms (diagnosis, drug therapy)
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Vincristine (therapeutic use)

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