[Complete remission obtained in advanced testicular cancer treated by etoposide (NK-171)].

Abstract

A 38-year-old man was admitted to Nara Medical University Hospital on Feb.7,1983, because of swelling of the scrotal contents on the right side and elevated serum AFP, beta-HCG and LDH suggestive of testicular tumor. Right orchiectomy was carried out and a pathological diagnosis of embryonal cell carcinoma of the right testis (pT3N0M1) was made. The patient, upon evidence of multiple pulmonary metastases, was treated with a combination chemotherapy of cis-Diamminedichloroplatinum, vincristine and peplomycin. After three courses of combination chemotherapy, pulmonary metastases were decreased, but their foci persisted. The patient was then treated with Etoposide 62 mg/m2 daily for 5 days every three weeks, and after this course, complete remission of pulmonary metastases was obtained. The patient recieved 3 courses of Etoposide and retroperitoneal lymph node dissection, and has since shown no evidence of disease for 2 years and 4 months after surgery.

• Authors: K Babaya, K Tsumatani, O Natsume, T Yoshie, K Kubota, S Ozono, Y Hirao, E Okajima
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 13 Issue 3 Pt 1 Pg. 604-7 (Mar 1986) ISSN: 0385-0684 [Print] Japan
• PMID: 2420282 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Bleomycin
• Peplomycin
• Vincristine
• Etoposide
• Podophyllotoxin
• Cisplatin

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bleomycin (administration & dosage)
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Drug Administration Schedule
• Etoposide (therapeutic use)
• Humans
• Lung Neoplasms (secondary)
• Lymph Node Excision
• Male
• Peplomycin
• Podophyllotoxin (analogs & derivatives)
• Teratoma (drug therapy, pathology, surgery)
• Testicular Neoplasms (drug therapy, pathology, surgery)
• Vincristine (administration & dosage)