Abstract | OBJECTIVE: METHOD: Ninety male rats were randomly divided into 6 groups: the normal group, the model group, TSD high-, medium- and low-dose (300, 100, 30 mg x kg(-1)) groups and the benzbromarone (10 mg x kg(-1)) group. Potassium oxonate and ethambutol were adopted to establish the chronic hyperuricemia model Since the third week, all the rats were intragastrically administered with drugs for 4 weeks, once a day, in order to determine their uric acid in serum and urine, uric acid excretion and xanthine oxidase (XOD). URAT1 mRNA and URAT1 protein expression in rat renal tubular cells were determined by RT-PCR and immunohistochemistry method respectively. RESULT: CONCLUSION: TSD has an obvious effect of anti- hyperuricemia It may reduce the reabsorption of uric acid by inhibiting the high expression of rat renal URAT1.
|
Authors | Guang-Liang Chen, Li-Ran Zhu, Sha Na, Li Li |
Journal | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
(Zhongguo Zhong Yao Za Zhi)
Vol. 38
Issue 14
Pg. 2348-53
(Jul 2013)
ISSN: 1001-5302 [Print] China |
PMID | 24199570
(Publication Type: Journal Article)
|
Chemical References |
- Anion Transport Proteins
- Gout Suppressants
- Saponins
- Slc22a12 protein, rat
- Uric Acid
- Benzbromarone
- Xanthine Oxidase
|
Topics |
- Animals
- Anion Transport Proteins
(biosynthesis, genetics, metabolism)
- Benzbromarone
(pharmacology)
- Dioscorea
(chemistry)
- Gout Suppressants
(chemistry, pharmacology)
- Hyperuricemia
(blood, drug therapy, genetics, urine)
- Kidney Tubules
(drug effects, metabolism)
- Male
- Rats
- Rats, Sprague-Dawley
- Saponins
(chemistry, pharmacokinetics, pharmacology)
- Uric Acid
(blood, urine)
- Xanthine Oxidase
(metabolism)
|