Adrenergic metabolic and hemodynamic effects of octopamine in the liver.

The fruit extracts of Citrus aurantium (bitter orange) are traditionally used as weight-loss products and as appetite suppressants. A component of these extracts is octopamine, which is an adrenergic agent. Weight-loss and adrenergic actions are always related to metabolic changes and this work was designed to investigate a possible action of octopamine on liver metabolism. The isolated perfused rat liver was used to measure catabolic and anabolic pathways and hemodynamics. Octopamine increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure. Octopamine also accelerated the oxidation of exogenous fatty acids (octanoate and oleate), as revealed by the increase in ¹⁴CO₂ production derived from ¹⁴C labeled precursors. The changes in glycogenolysis, oxygen uptake and perfusion pressure were almost completely abolished by α₁-adrenergic antagonists. The same changes were partly sensitive to the β-adrenergic antagonist propranolol. It can be concluded that octopamine accelerates both catabolic and anabolic processes in the liver via adrenergic stimulation. Acceleration of oxygen uptake under substrate-free perfusion conditions also means acceleration of the oxidation of endogenous fatty acids, which are derived from lipolysis. All these effects are compatible with an overall stimulating effect of octopamine on metabolism, which is compatible with its reported weight-loss effects in experimental animals.
AuthorsAndrea Luiza de Oliveira, Mariana Nascimento de Paula, Jurandir Fernando Comar, Vanessa Rodrigues Vilela, Rosane Marina Peralta, Adelar Bracht
JournalInternational journal of molecular sciences (Int J Mol Sci) Vol. 14 Issue 11 Pg. 21858-72 ( 2013) ISSN: 1422-0067 [Electronic] Switzerland
PMID24196353 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Obesity Agents
  • Appetite Depressants
  • Caprylates
  • octanoic acid
  • Octopamine
  • Animals
  • Anti-Obesity Agents (chemistry, pharmacology)
  • Appetite Depressants (chemistry, pharmacology)
  • Caprylates (metabolism)
  • Citrus (chemistry)
  • Hemodynamics (drug effects)
  • Lipolysis (drug effects)
  • Liver (drug effects, metabolism)
  • Octopamine (chemistry, metabolism, pharmacology)
  • Oxidation-Reduction (drug effects)
  • Rats

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