Photocontrolled nuclear-targeted drug delivery by single component photoresponsive fluorescent organic nanoparticles of acridin-9-methanol.

Abstract

We report for the first time an organic nanoparticle based nuclear-targeted photoresponsive drug delivery system (DDS) for regulated anticancer drug release. Acridin-9-methanol fluorescent organic nanoparticles used in this DDS performed three important roles: (i) ″nuclear-targeted nanocarrier″ for drug delivery, (ii) ″phototrigger″ for regulated drug release, and (iii) fluorescent chromophore for cell imaging. In vitro biological studies reveal acridin-9-methanol nanoparticles of ~60 nm size to be very efficient in delivering the anticancer drug chlorambucil into the target nucleus, killing the cancer cells upon irradiation. Such targeted organic nanoparticles with good biocompatibility, cellular uptake property, and efficient photoregulated drug release ability will be of great benefit in the field of targeted intracellular controlled drug release.

• Authors: Avijit Jana, Biswajit Saha, Deb Ranjan Banerjee, Sudip Kumar Ghosh, Kim Truc Nguyen, Xing Ma, Qiuyu Qu, Yanli Zhao, N D Pradeep Singh
• Journal: Bioconjugate chemistry (Bioconjug Chem) Vol. 24 Issue 11 Pg. 1828-39 (Nov 20 2013) ISSN: 1520-4812 [Electronic] United States
• PMID: 24195782 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acridines
• Antineoplastic Agents
• Fluorescent Dyes
• Chlorambucil

Topics

• Acridines (chemical synthesis, chemistry)
• Antineoplastic Agents (metabolism, pharmacology)
• Cell Nucleus (metabolism)
• Cell Proliferation (drug effects)
• Chlorambucil (metabolism, pharmacology)
• Drug Delivery Systems
• Drug Screening Assays, Antitumor
• Fluorescent Dyes (chemical synthesis, chemistry, radiation effects)
• HeLa Cells
• Humans
• Hydrogen-Ion Concentration
• Molecular Docking Simulation
• Nanoparticles (chemistry, radiation effects)
• Photochemical Processes
• Photolysis