Abstract | AIM: METHODS: In our institution, from October 1995 to June 2012, about 550 operations for PC were performed; in 300 cases cytoreduction plus HIPEC was carried out. Out of 90 operations for colonic cancer: 50 cytoreduction plus HIPEC, 12 cytoreduction and EPIC (early postoperative intraperitoneal chemotherapy) and 28 debulking or explorative laparoscopies/ laparotomies were performed. For the present study, 50 patients who had undergone cytoreduction and HIPEC for PC of colorectal cancer origin (CRC) were considered. RESULTS: The morbidity and mortality rates were 34% (17/50) and 2% (1/50), respectively. The patients were divided in two groups according to PCI (peritoneal cancer index, range 0-39) and CC score (completeness of cytoreduction): in Group A (23 patients, PCI>16, CC-2) the median survival time was 15 months compared to 48.1 months for Group B (27 patients, PCI≤16, CC-0/1). The poor survival of Group A seemed to be related to higher PCI and CC score. CONCLUSION: Patient selection based on a maximum PCI of 16 associated with a complete cytoreduction (CC-0) produced encouraging results.
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Authors | M Robella, M Vaira, P Marsanic, A Mellano, A Cinquegrana, A Sottile, M De Simone |
Journal | Minerva chirurgica
(Minerva Chir)
Vol. 68
Issue 6
Pg. 551-8
(Dec 2013)
ISSN: 0026-4733 [Print] Italy |
PMID | 24193287
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Aged
- Carcinoma
(mortality, secondary, surgery, therapy)
- Chemotherapy, Cancer, Regional Perfusion
- Colonic Neoplasms
(pathology)
- Combined Modality Therapy
- Female
- Humans
- Hyperthermia, Induced
- Male
- Middle Aged
- Patient Selection
- Peritoneal Neoplasms
(mortality, secondary, surgery, therapy)
- Survival Rate
- Treatment Outcome
- Young Adult
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