Abstract |
Pharmacological doses of ceruletide administered intravenously to unconscious rats uniformly induces acute pancreatitis (AP) as well as a striking reduction in pure pancreatic juice (PPJ) and protein output. High-dose intravenous secretin administered to rats with ceruletide-induced AP effects a reestablishment of PPJ flow and a significant increase in PPJ protein output. Light microscopy of the pancreas in ceruletide-induced AP rats revealed marked acinar cell vacuolization and intense interstitial edema. By contrast, pancreatic histology in AP rats treated with high-dose secretin revealed a distinct lessening of acinar cell vacuolization and interstitial edema. We have established that high-dose intravenous secretin given to rats with ceruletide-induced AP is (1) not harmful, (2) reestablishes PPJ flow and evokes a partial restoration of protein output, and (3) appears to reduce pancreatic histopathology when compared to non- secretin-treated rats with AP.
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Authors | I G Renner, J R Wisner Jr, B C Lavigne |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 31
Issue 3
Pg. 305-13
(Mar 1986)
ISSN: 0163-2116 [Print] United States |
PMID | 2419062
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Proteins
- Secretin
- Ceruletide
- Amylases
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Topics |
- Acute Disease
- Amylases
(blood)
- Animals
- Ceruletide
- Disease Models, Animal
- Infusions, Parenteral
- Male
- Pancreas
(drug effects, pathology, physiopathology)
- Pancreatic Juice
(metabolism)
- Pancreatitis
(chemically induced, physiopathology)
- Proteins
(metabolism)
- Rats
- Rats, Inbred Strains
- Secretin
(administration & dosage)
- Time Factors
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