Abstract | CONTEXT: OBJECTIVE: DESIGN: A cross-sectional echocardiographic study was performed in a large group of patients who were receiving dopamine agonist therapy for hyperprolactinemia. Studies were performed in accordance with the British Society of Echocardiography minimum dataset for a standard adult transthoracic echocardiogram. Poisson regression was used to calculate relative risks according to quartiles of dopamine agonist cumulative dose using the lowest cumulative dose quartile as the reference group. SETTING: Twenty-eight centers of secondary/tertiary endocrine care across the United Kingdom participated in the study. RESULTS: Data from 747 patients (251 males; median age, 42 y; interquartile range [IQR], 34-52 y) were collected. A total of 601 patients had taken cabergoline alone; 36 had been treated with bromocriptine alone; and 110 had received both drugs at some stage. The median cumulative dose for cabergoline was 152 mg (IQR, 50-348 mg), and for bromocriptine it was 7815 mg (IQR, 1764-20 477 mg). A total of 28 cases of moderate valvular stenosis or regurgitation were observed in 24 (3.2%) patients. No associations were observed between cumulative doses of dopamine agonist used and the age-corrected prevalence of any valvular abnormality. CONCLUSION: This large UK cross-sectional study does not support a clinically concerning association between the use of dopamine agonists for the treatment of hyperprolactinemia and cardiac valvulopathy.
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Authors | W M Drake, C E Stiles, T A Howlett, A A Toogood, J S Bevan, R P Steeds, UK Dopamine Agonist Valvulopathy Group |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 99
Issue 1
Pg. 90-6
(Jan 2014)
ISSN: 1945-7197 [Electronic] United States |
PMID | 24187407
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dopamine Agonists
- Ergolines
- Ergot Alkaloids
- Cabergoline
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Topics |
- Adult
- Cabergoline
- Cross-Sectional Studies
- Dopamine Agonists
(therapeutic use)
- Echocardiography
- Ergolines
(therapeutic use)
- Ergot Alkaloids
(therapeutic use)
- Female
- Heart Valve Diseases
(chemically induced, diagnostic imaging, epidemiology)
- Humans
- Hyperprolactinemia
(diagnostic imaging, drug therapy, epidemiology)
- Male
- Middle Aged
- Prevalence
- United Kingdom
(epidemiology)
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