Pancreatic carcinoma in childhood. Report of an autopsy case and a review of the literature.

Clinical and histological findings of pancreatic carcinoma in a 6-year-old boy are reported. Gradual change of histological appearance of the tumor during his course of 3 years and elevation of serum alpha-1-fetoprotein (AFP) are documented. Two biopsy specimens showed immature histological appearance compatible with pancreatoblastoma, and autopsy material showed well-differentiated adenocarcinoma with distinct ductal and acinar differentiation. Electron microscopy demonstrated zymogen-like granules in the apical portion of the neoplastic cells. Immunoperoxidase method demonstrated AFP in the neoplastic cells in addition to alpha-1-antitrypsin. Literature of pancreatic tumor in the young was reviewed, and characteristics of this case were discussed.
AuthorsY Ohaki, K Misugi, Y Sasaki, M Okudaira
JournalActa pathologica japonica (Acta Pathol Jpn) Vol. 35 Issue 6 Pg. 1543-54 (Nov 1985) ISSN: 0001-6632 [Print] JAPAN
PMID2418627 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Neoplasm Proteins
  • alpha 1-Antitrypsin
  • alpha-Fetoproteins
  • Adenocarcinoma (analysis, pathology, secondary)
  • Child
  • Cytoplasmic Granules (analysis)
  • Humans
  • Immunoenzyme Techniques
  • Liver Neoplasms (analysis, secondary)
  • Male
  • Neoplasm Proteins (analysis)
  • Pancreatic Neoplasms (analysis, pathology)
  • alpha 1-Antitrypsin (analysis)
  • alpha-Fetoproteins (analysis)

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