Abstract | BACKGROUND: METHODS: RESULTS: Time to target esophageal temperature was less than 5 min in the TLV group. Hypothermia was accompanied by preserved renal function in the TLV group as compared with control group regarding numerous markers including creatinine blood levels (12 ± 1 vs. 16 ± 2 mg/l, respectively; mean ± SEM), urinary N-acetyl-β-(D)- glucosaminidase (1.70 ± 0.11 vs. 3.07 ± 0.10 U/mol of creatinine), γ-glutamyltransferase (8.36 ± 0.29 vs. 12.96 ± 0.44 U/mol of creatinine), or β2-microglobulin (0.44 ± 0.01 vs. 1.12 ± 0.04 U/mol of creatinine). Kidney lesions evaluated by electron microscopy and conventional histology were also attenuated in TLV versus control groups. The renal-protective effect of TLV was not related to differences in delayed inflammatory or immune renal responses because transcriptions of, for example, interferon-γ, tumor necrosis factor-α, interleukin-1β, monocyte chemoattractant protein-1, toll-like receptor-2, toll-like receptor-4, and vascular endothelial growth factor were similarly altered in TLV and control versus Sham. CONCLUSION: Ultrafast cooling with TLV is renal protective after cardiac arrest and resuscitation, which could increase kidney availability for organ donation.
|
Authors | Renaud Tissier, Sebastien Giraud, Nathalie Quellard, Béatrice Fernandez, Fanny Lidouren, Lys Darbera, Matthias Kohlhauer, Sandrine Pons, Mourad Chenoune, Patrick Bruneval, Jean-Michel Goujon, Bijan Ghaleh, Alain Berdeaux, Thierry Hauet |
Journal | Anesthesiology
(Anesthesiology)
Vol. 120
Issue 4
Pg. 861-9
(Apr 2014)
ISSN: 1528-1175 [Electronic] United States |
PMID | 24185488
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Topics |
- Animals
- Disease Models, Animal
- Heart Arrest
(complications)
- Hypothermia, Induced
(methods)
- Kidney
(physiopathology)
- Kidney Diseases
(complications, prevention & control)
- Kidney Function Tests
- Liquid Ventilation
(methods)
- Rabbits
- Treatment Outcome
|