Turnover of alpha-2-antiplasmin in patients with acute promyelocytic leukemia.

Abstract

Patients with acute promyelocytic leukemia have a bleeding disorder which was thus far explained by a coagulopathy based on diffuse intravascular coagulation (DIC). We observed severe alpha-2-antiplasmin deficiency in a consecutive series of such patients. We postulate proteolysis rather than DIC, also because of increased turnover of 125I-alpha-2-antiplasmin, to be responsible for the coagulopathy. Alpha-2-antiplasmin deficiency may well contribute to the bleeding disorder in acute promyelocytic leukemia.

• Authors: L H Kahle, G Avvisati, R J Lamping, T Moretti, F Mandelli, J W ten Cate
• Journal: Scandinavian journal of clinical and laboratory investigation. Supplementum (Scand J Clin Lab Invest Suppl) Vol. 178 Pg. 75-80 ( 1985) ISSN: 0085-591X [Print] Norway
• PMID: 2418490 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Blood Coagulation Factors
• alpha-2-Antiplasmin
• Antithrombin III
• Plasminogen

Topics

• Antithrombin III (analysis)
• Blood Coagulation Factors (analysis)
• Blood Coagulation Tests
• Humans
• Leukemia, Myeloid, Acute (blood, drug therapy)
• Plasminogen (analysis)
• Platelet Count
• Reference Values
• alpha-2-Antiplasmin (deficiency, metabolism)