Abstract | AIM: To describe drugs targeting urethra and prostate to treat dysfunctions such LUTS related to BPH, primary bladder neck obstruction (PBNO), detrusor sphincter dyssynergia (DSD) or sphincter deficiency (SD). METHOD: Pubmed search for efficacy, mode of action and side effects for each molecule. Additional data were searched from the French regulatory agencies web sites (HAS and ANSM). RESULTS: CONCLUSION: Armamenterium to treat urethral dysfunctions has recently increases. Two new therapeutic classes emerge: PDE5Is to treat LUTS related to BPH and an SRIs ( Duloxetine) to treat stress urinary incontinence. Efficacy and safety evaluation of all the possible associations between drugs targeting urethra and/or bladder is needed to a subtler and more efficient pharmacologic modulation of lower urinary tract dysfunction.
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Authors | X Game, J-N Cornu, G Robert, A Descazeaud, S Droupy, A Benard-Laribiere, C Bastide, L Guy, F Bruyére, G Karsenty |
Journal | Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie
(Prog Urol)
Vol. 23
Issue 15
Pg. 1287-98
(Nov 2013)
ISSN: 1166-7087 [Print] France |
Vernacular Title | Les médicaments de l'urètre. |
PMID | 24183087
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2013. Published by Elsevier Masson SAS. |
Chemical References |
- 5-alpha Reductase Inhibitors
- Adrenergic alpha-Antagonists
- Androgen Antagonists
- Fatty Alcohols
- Neuromuscular Agents
- Phosphodiesterase 5 Inhibitors
- Plant Extracts
- Serotonin Uptake Inhibitors
- Tadenan
- Botulinum Toxins, Type A
- saw palmetto extract
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Topics |
- 5-alpha Reductase Inhibitors
(therapeutic use)
- Adrenergic alpha-Antagonists
(therapeutic use)
- Androgen Antagonists
(therapeutic use)
- Botulinum Toxins, Type A
(therapeutic use)
- Fatty Alcohols
(therapeutic use)
- Humans
- Male
- Neuromuscular Agents
(therapeutic use)
- Phosphodiesterase 5 Inhibitors
(therapeutic use)
- Phytotherapy
- Plant Extracts
(therapeutic use)
- Prostatic Hyperplasia
(drug therapy)
- Prunus africana
- Serenoa
- Selective Serotonin Reuptake Inhibitors
(therapeutic use)
- Urethral Diseases
(drug therapy)
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