Abstract | OBJECTIVE: METHODS: Thirty chinchilla were exposed to a 105 dB octave band noise centered at 4 kHz for 6 h and randomly assigned to a control group (saline only) and three experimental groups [4-OHPBN (10 mg/kg) plus NAC (20 mg/kg), 4-OHPBN (20 mg/kg) plus NAC (50 mg/kg), and 4-OHPBN (50 mg/kg) plus NAC (100 mg/kg)]. The drugs were orally administrated beginning 4 h after noise exposure and then administered twice daily for the next 2 days. Permanent auditory brainstem response threshold shifts, distortion product otoacoustic emission threshold shifts, and the percentage of missing outer hair cell were determined. RESULTS: The oral administration significantly reduced permanent hearing threshold shift, distortion product otoacoustic emission threshold shift, and the percentage of missing outer hair cell in a dose-dependent manner. DISCUSSION:
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Authors | C-H Choi, X Du, R A Floyd, R D Kopke |
Journal | Free radical research
(Free Radic Res)
Vol. 48
Issue 3
Pg. 264-72
(Mar 2014)
ISSN: 1029-2470 [Electronic] England |
PMID | 24182331
(Publication Type: Journal Article)
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Chemical References |
- 4-hydroxyphenyl tert-butylnitrone
- Antioxidants
- Imines
- Phenols
- Acetylcysteine
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Topics |
- Acetylcysteine
(pharmacology)
- Administration, Oral
- Animals
- Antioxidants
(pharmacology)
- Apoptosis
(drug effects)
- Chinchilla
- Dose-Response Relationship, Drug
- Female
- Hearing Loss, Noise-Induced
(drug therapy, etiology, pathology)
- Imines
(pharmacology)
- Phenols
(pharmacology)
- Random Allocation
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