Abstract | BACKGROUND: METHODS/DESIGN: The PROPER II study is a multi-center cluster randomized controlled, pragmatic trial using parallel groups. It has a duration of eighteen months and four six-monthly assessments. Six nursing homes will participate in the intervention and six will continue care as usual. The nursing homes will be located throughout the Netherlands, each participating with two dementia special care units with an average of fifteen patients per unit, resulting in 360 patients. The intervention consists of a structured and repeated multidisciplinary medication review supported by education and continuous evaluation. It is conducted by pharmacists, physicians, and nurses and consists of three components: 1) preparation and education, 2) conduct, and 3) evaluation/guidance. The primary outcome is the proportion of patients with appropriate psychotropic drug use. Secondary outcomes are the overall frequency of psychotropic drug use, neuropsychiatric symptoms, quality of life, activities of daily living, psychotropic drug side effects and adverse events (including cognition, comorbidity, and mortality). Besides, a process analysis on the intervention will be carried out. DISCUSSION: This study is expected to improve the appropriateness of psychotropic drug prescription for neuropsychiatric symptoms in nursing home patients with dementia by introducing a structured and repeated multidisciplinary medication review supported by education and continuous evaluation. TRIAL REGISTRATION: Netherlands Trial Registry (NTR): NTR3569.
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Authors | Claudia H W Smeets, Martin Smalbrugge, Debby L Gerritsen, Marjorie H J M G Nelissen-Vrancken, Roland B Wetzels, Klaas van der Spek, Sytse U Zuidema, Raymond T C M Koopmans |
Journal | BMC psychiatry
(BMC Psychiatry)
Vol. 13
Pg. 280
(Nov 01 2013)
ISSN: 1471-244X [Electronic] England |
PMID | 24180295
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Activities of Daily Living
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Clinical Protocols
- Dementia
(drug therapy, psychology)
- Drug Prescriptions
- Humans
- Netherlands
- Nursing Homes
- Psychotropic Drugs
(therapeutic use)
- Quality of Life
- Research Design
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