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Reduced collagen content and fibre bundle disorganization in skin biopsies of patients with Ehlers-Danlos syndrome.

Abstract
Skin biopsies from 25 patients with the Ehlers-Danlos Syndrome and 15 site, sex and age matched controls were studied by the picrosirius polarization procedure, a specific method for collagen detection in tissue sections. When used in conjunction with histophotometry, this technique permits a quantitative assay of collagen content in the dermis. The light emission measurements obtained showed a statistically significant reduction in the dermal collagen density of Ehlers-Danlos syndrome patients as compared to their controls. Qualitatively, the dermal collagen fibres of these patients appeared frayed and of reduced diameter. These findings indicate that collagen is quantitatively decreased in skin biopsies of patients with the Ehlers-Danlos syndrome.
AuthorsL C Junqueira, J T Roscoe
JournalThe Histochemical journal (Histochem J) Vol. 17 Issue 11 Pg. 1197-202 (Nov 1985) ISSN: 0018-2214 [Print] Netherlands
PMID2417992 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Collagen
Topics
  • Biopsy
  • Collagen (analysis)
  • Ehlers-Danlos Syndrome (metabolism, pathology)
  • Humans
  • Microscopy, Polarization
  • Skin (analysis, pathology)
  • Staining and Labeling

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