Abstract | BACKGROUND: PATIENTS AND METHODS: Subjects with class 6 venous ulcers (CEAP classification) of at least 6 months duration were prospectively recruited. The ointment was administered daily and follow-up visits were conducted on the fifth, 10th, 15th and 20th days. On each visit the necrotic area was measured with a grid. The moisture balance, odour, viability of non-necrotic areas and the presence of erythema were also assessed. Primary outcome was the percentage of subjects with complete debridement, secondary outcomes the time to complete healing, reduction of the lesion area, absence of necrotic tissue, presence of odor, erythema, hydration, any adverse events. RESULTS: One hundred subjects were enrolled in four centres. All patients achieved complete debridement of the necrotic area and a significant reduction of the total ulcer area by day 20, while other parameters improved significantly over time. Only two patients experienced a transient leg oedema. CONCLUSIONS:
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Authors | G Gravante, R Sorge, N Giordan, S R Georgescu, S H Morariu, I Stoicescu, V Clatici |
Journal | European review for medical and pharmacological sciences
(Eur Rev Med Pharmacol Sci)
Vol. 17
Issue 20
Pg. 2721-7
(Oct 2013)
ISSN: 1128-3602 [Print] Italy |
PMID | 24174353
(Publication Type: Clinical Trial, Journal Article, Multicenter Study)
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Chemical References |
- Ointments
- Hyaluronic Acid
- Collagenases
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Topics |
- Aged
- Chronic Disease
- Collagenases
(administration & dosage)
- Debridement
- Female
- Humans
- Hyaluronic Acid
(administration & dosage)
- Male
- Middle Aged
- Ointments
- Pilot Projects
- Prospective Studies
- Varicose Ulcer
(drug therapy)
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