Abstract | INTRODUCTION: METHODOLOGY: This study was conducted in SCB Medical College, Cuttack. 60 rats were fed on atherogenic diet. These were divided in six groups having ten rats in each group and followed for 12 weeks. Group I received only atherogenic diet. All other groups received drugs after four weeks. Group II received Ezetimibe 1mg/kg, Group III received Ezetimibe 2mg/kg, Group IV received Atorvastatin 4mg/kg, Group V received Atorvastatin 8mg/kg and Group VI received Atorvastatin 4mg/kg and Ezetimibe 1mg/kg. Blood lipid profile measured at zero week, four weeks and 12 weeks. RESULTS: All the lipid profile parameters improved significantly with treatment groups as compared with control group. There was no significant difference in the level of different lipid parameters between Group V ( Atorvastatin 8mg/kg) and Group VI ( Atorvastatin 4mg/kg and Ezetimibe 1mg/kg). CONCLUSION: High dose of Atorvastatin is associated with more adverse effect. The efficacy of high dose of Atorvastatin is comparable to combination of low dose Atorvastatin with Ezetimibe. This combination has lesser side effects. So, this can be a good alternative.
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Authors | Anju Prasad, Pratyay Pratim Datta, Ritesh Roy, Chaitali Pattanayak, Parbaty Panda |
Journal | Materia socio-medica
(Mater Sociomed)
Vol. 25
Issue 3
Pg. 192-5
( 2013)
ISSN: 1512-7680 [Print] Bosnia and Herzegovina |
PMID | 24167434
(Publication Type: Journal Article)
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