Heart transplantation for Chagas cardiomyopathy in the United States.

Abstract

Since an initial case in 2006, we noted multiple patients undergoing heart transplantation (HTx) for Chagas cardiomyopathy (CC) at our transplant program. The clinical characteristics, laboratory results and outcomes of patients with CC undergoing HTx in the United States have not been reported previously. In 2010, we implemented a systematic screening and management program for patients undergoing HTx for CC. Before HTx, all patients with idiopathic dilated cardiomyopathy who were born in a Chagas disease endemic country were screened for Trypanosoma cruzi (TC) infection with serology. After HTx, monitoring for TC reactivation was performed using clinical visits, echocardiography, endomyocardial biopsy and serial whole blood polymerase chain reaction (PCR) testing. Between June 2006 and January 2012, 11 patients underwent HTx for CC. One patient was empirically treated due to the presence of TC amastigotes in explanted cardiac tissue. Two patients experienced allograft dysfunction due to TC reactivation and three patients experienced subclinical reactivation (positive PCR results), which were treated. Chagas disease is a common cause of dilated cardiomyopathy in patients from endemic countries undergoing HTx at a transplant program in the United States. Reactivation is common after transplantation and can cause adverse outcomes.

• Authors: E P Kransdorf, L S C Czer, D J Luthringer, J K Patel, S P Montgomery, A Velleca, J Mirocha, P C Zakowski, R Zabner, C R Gaultier, Y Qvarnstrom, T Benedict, F Steurer, E Bosserman, C D Paddock, M Rafiei, J A Kobashigawa
• Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (Am J Transplant) Vol. 13 Issue 12 Pg. 3262-8 (Dec 2013) ISSN: 1600-6143 [Electronic] United States
• PMID: 24165397 (Publication Type: Journal Article)
• Copyright: © Copyright 2013 The American Society of Transplantation and the American Society of Transplant Surgeons.

Topics

• Adult
• Aged
• Belize
• Biopsy
• Chagas Cardiomyopathy (parasitology, therapy)
• Echocardiography
• El Salvador
• Female
• Graft Survival
• Heart Transplantation
• Humans
• Male
• Mexico
• Middle Aged
• Polymerase Chain Reaction
• Recurrence
• Trypanosoma cruzi (genetics)
• United States